Researchers
Wessels, Arno PHD
Medical University of South Carolina
INCLUDE Grants
Mechanisms of DMP Development and Atrioventricular Septation
Grant Number
R01HL122906
NIH Institute
NHLBI
Mechanism
R01
Around one in every hundred babies is born with a congenital heart abnormality. In our research
program we are studying the role of the second heart field in the pathogenesis of congenital heart
disease. In this project we specifically focus on the role of SOX family members in outflow and
ventricular septal defects.
Exploring the Role of the anterior SHF in AVSD Pathogenesis
Grant Number
3R01HL122906-07S1
NIH Institute
NHLBI
Mechanism
R01
Atrioventricular defects (AVSDs) are complex heart malformations found in 35-40% of individuals with Down syndrome. The research proposed in this Supplement is aimed at determining the role of the Second Heart Field in the pathogenesis of the respective morphological components that form part of the AVSD spectrum. Elucidating the molecular and cellular mechanisms underlying the pathogenesis of AVSDs could lead to strategies to prevent and/or treat this severe congenital defect.