Exploring the Role of the anterior SHF in AVSD Pathogenesis

Atrioventricular defects (AVSDs) are complex heart malformations found in 35-40% of individuals with Down syndrome. The research proposed in this Supplement is aimed at determining the role of the Second Heart Field in the pathogenesis of the respective morphological components that form part of the AVSD spectrum. Elucidating the molecular and cellular mechanisms underlying the pathogenesis of AVSDs could lead to strategies to prevent and/or treat this severe congenital defect.