William, Christopher Maged MD

The proposed research is relevant to public health because this work will provide a new perspective on the molecular pathogenesis of Down syndrome (DS), the most common genetic cause of intellectual disability, which will enable the identification of new drug targets and provide an approach to test candidate therapies to prevent developmental delay and cognitive impairment in individuals with DS. The proposed research is relevant to the NIH’s mission “to seek fundamental knowledge about the nature and behavior of living systems and the applica- tion of that knowledge to enhance health, lengthen life, and reduce illness and disability.” This work will also help to achieve goals of the NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndrome (INCLUDE) Project to “improve understanding of the biology of Down syndrome and support development of new treatments for health conditions experienced by individuals with Down syndrome.”