Rosas, Herminia Diana MD

Alterations in mitochondrial ATP production and redox homeostasis in brain mitochondria are strongly associated with pathogenesis in Down syndrome (DS) and Alzheimer disease. We propose to optimize [18F]-BCPP-EF PET imaging for the robust assessment of Mitochondrial Complex I function in living individuals with DS and for whom alterations in mitochondrial bioenergetics are well established, with an overall goal of providing new in vivo information that contributes new knowledge about the risk for AD in people with DS.