Researchers
Pierce, Jonathan Thomas PHD
University of Texas at Austin
INCLUDE Grants
Supplement to: Systematic functional study of 21st chromosome ortholog overexpression in C. elegans
Grant Number
3R21OD032463-01S1
NIH Institute
OD
Mechanism
R21
People with Down syndrome inherit an extra copy of the 21st chromosome which carries about 200 genes. It remains unclear which of these genes contribute to the wide variety of developmental and physiological phenotypes in DS. The proposed research uses an innovative screening strategy to systematically study the phenotypic consequence of adding and subtracting each of these genes in a powerful animal model.
Systematic functional study of 21st chromosome ortholog overexpression in C. elegans
Grant Number
3R21OD032463-01S2
NIH Institute
OD
Mechanism
R21
People with Down syndrome inherit an extra copy of the 21st chromosome which carries about 200 genes. It remains unclear which of these genes contribute to the wide variety of developmental and physiological phenotypes in DS. The proposed research uses an innovative screening strategy to systematically study the phenotypic consequence of adding and subtracting each of these genes in a powerful animal model.