Researchers
Ledreux, Aurelie PHD
University of Denver
INCLUDE Grants
Noradrenergic dysfunction in Down Syndrome
Grant Number
R01AG070153
NIH Institute
NIA
Mechanism
R01
Down syndrome (DS) is a genetic condition that occurs in 1 out of 700 births with more than 350,000 Americans affected. Alzheimer's disease (AD) occurs with high penetrance in DS and few treatment options are available. Data obtained from this project can translate to treatment potentials in AD in the general population and are focused on noradrenergic systems and inflammation.
Publications
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Alzheimer's & dementia : the journal of the Alzheimer's Association
Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome. -
Journal of Alzheimer's disease : JAD
Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome.