Hom, Christy

The Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS) study is a five-year, longitudinal deep-phenotyping study of factors driving the risk and severity of co-occurring conditions in children, adolescents, and young adults with Down syndrome, funded by the NIH INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE). The study involves a rigorous protocol for understanding the complex interplay between trisomy 21, metabolic dysregulation, obesity, lifestyle, and the development of co-occurring conditions across childhood, adolescence, and into young adulthood in people with Down syndrome. This effort will enroll 200 participants (ages 6-24 years of age) with Down syndrome from four clinical performance sites, and track conditions and variables across 3 data collection cycles.