Researchers
Brickman, Adam M PHD
Columbia University Medical Center
INCLUDE Grants
Cerebrovascular contributions to Alzheimer’s disease in adults with Down Syndrome
Grant Number
RF1AG079519
NIH Institute
NIA
Mechanism
RF1
This project will examine neuroimaging, blood-based, and neuropathological markers of the vascular contributions to cognitive impairment and Alzheimer's disease (AD) in adults with Down syndrome (DS). Adults with DS are living much longer than previously, but virtually all develop the pathology and symptoms of AD by late adulthood. By examining the cerebrovascular component of AD and cognitive decline in adults with DS, this study will identify potential targets to mitigate the emerging public health crisis in this population and inform similar interventions in the neurotypical population.
Publications
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Alzheimer's & dementia : the journal of the Alzheimer's Association
Alzheimer’s disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Examination of metabolic syndrome in Down syndrome and association with dementia. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer’s continuum in adults with Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Age and sex are associated with Alzheimer’s disease neuropathology in Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Longitudinal study of body mass index in relation to Alzheimer’s disease pathology and symptomatology in Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
The Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Resistance and resilience to Alzheimer’s disease in Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Decoding brain structure to stage Alzheimer’s disease pathology in Down syndrome. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down’s syndrome. -
JAMA neurology
Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome. -
Scientific reports
Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome. -
The Lancet. Neurology
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. -
Alzheimer's & dementia : the journal of the Alzheimer's Association
Probing the proteome to explore potential correlates of increased Alzheimer’s-related cerebrovascular disease in adults with Down syndrome. -
Disability and health journal
Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. -
Alzheimer's & dementia (Amsterdam, Netherlands)
Joint-label fusion brain atlases for dementia research in Down syndrome. -
Sleep advances : a journal of the Sleep Research Society
Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer’s continuum.