The role of APP in neurogenesis and AD in Down syndrome

Lazarov, Orly

Summary

This project examines the role of amyloid precursor protein overexpression in cortical malformation and Alzheimer’s disease in Down syndrome using induced pluripotent stem cells of Down syndrome that were edited to eliminate one APP allele.

Grant Number

RF1AG079002

NIH Institute

NIA

Mechanism

RF1

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