MA, SAI PHD, BS

PROJECT NARRATIVE DNA a to on hematopoietic therapeutic quality methylation is a crucial epigenetic mechanism that regulates genome function and RNA expression, playing pivotal role in the establishment, development, and maintenance of human hematopoiesis. This project aims investigate the unique DNA methylation patterns in trisomy 21-associated hematopoietic stem cells, focusing their impact on early cell fate decisions, self-renewal, and lineage priming, which predispose individuals to disorders and leukemia. An improved understanding of these mechanisms may reveal novel t argets for diseases associated with dysregulated DNA methylation, significantly enhancing the of life for individuals with Down syndrome.