Grants
Characterizing DNA Methylation Dynamics in Trisomy 21-Associated Hematopoiesis and Leukemia
Summary
PROJECT NARRATIVE
DNA
a
to
on
hematopoietic
therapeutic
quality
methylation is a crucial epigenetic mechanism that regulates genome function and RNA expression, playing
pivotal role in the establishment, development, and maintenance of human hematopoiesis. This project aims
investigate the unique DNA methylation patterns in trisomy 21-associated hematopoietic stem cells, focusing
their impact on early cell fate decisions, self-renewal, and lineage priming, which predispose individuals to
disorders and leukemia. An improved understanding of these mechanisms may reveal novel
t argets for diseases associated with dysregulated DNA methylation, significantly enhancing the
of life for individuals with Down syndrome.