SIM2 Regulation of Mitochondrial Dysfunction in Down Syndrome

Porter, Weston W

Summary

Mitochondrial dysfunction and oxidative stress are major causal factors promoting Down Syndrome pathologies. Determining the interconnections between SIM2 and mitochondrial activity will provide a better understanding of the pathways driving mitochondrial dysfunction in Down Syndrome and a novel target for therapeutic treatment.

Grant Number

R01HD111848

NIH Institute

NICHD

Mechanism

R01

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