Researchers
Jaiswal, Jyoti K PHD
Children's National Medical Center
INCLUDE Grants
Molecular mechanism of dysregulated airway antiviral responses in children with Trisomy 21
Grant Number
R01HL159595
NIH Institute
NHLBI
Mechanism
R01
Statement: We will elucidate the mechanism mediating the dysregulation of airway antiviral and antioxidative responses in Down Syndrome (DS). This may provide the foundation to develop novel approaches to prevent severe respiratory infections caused by RSV and other viruses (e.g. SARS-CoV-2) in children and adults with DS.
IFN responses and SARS-CoV-2 Receptor ACE2 Expression in the airway epithelium of young children with Down Syndrome
Grant Number
3R01HL141237-02S1
NIH Institute
NHLBI
Mechanism
R01
Statement: We will elucidate the antiviral, pro-inflammatory and IFN-induced responses in the nasal AECs of children with Down Syndrome (DS). This may provide the foundation to develop novel approaches to prevent severe respiratory infections caused by SARS-CoV-2 and other viruses (e.g. RSV) in children and adults with DS.