IFN responses and SARS-CoV-2 Receptor ACE2 Expression in the airway epithelium of young children with Down Syndrome

Statement: We will elucidate the antiviral, pro-inflammatory and IFN-induced responses in the nasal AECs of children with Down Syndrome (DS). This may provide the foundation to develop novel approaches to prevent severe respiratory infections caused by SARS-CoV-2 and other viruses (e.g. RSV) in children and adults with DS.