Researchers
Price, Julie C PHD
University of Pittsburgh
INCLUDE Grants
Imaging of Mitochondial Complex I function in Down Syndrome
Grant Number
R21AG086927
NIH Institute
NIA
Mechanism
R21
Alterations in mitochondrial ATP production and redox homeostasis in brain mitochondria are strongly associated with pathogenesis in Down syndrome (DS) and Alzheimer disease. We propose to optimize [18F]-BCPP-EF PET imaging for the robust assessment of Mitochondrial Complex I function in living individuals with DS and for whom alterations in mitochondrial bioenergetics are well established, with an overall goal of providing new in vivo information that contributes new knowledge about the risk for AD in people with DS.
Publications
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Alzheimer's & dementia : the journal of the Alzheimer's Association
Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer’s disease: Cross-sectional associations with early cognitive impairments. -
The Lancet. Neurology
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study.