Researchers
Ge, Yubin PHD
Wayne State University
INCLUDE Grants
Enhancing treatments for myeloid leukemia associated with Down syndrome
Grant Number
R01CA290480
NIH Institute
NCI
Mechanism
R01
Down syndrome (DS) children have a significantly higher risk of developing acute leukemias compared to non- DS children. The goal of this proposal is to determine the role of the DS bone marrow microenvironment in myeloid leukemia associated with DS (ML-DS) therapy response, furthering our understanding of the mechanisms underlying the extremely high cure rates of children with ML-DS. This proposal will also identify a novel treatment strategy of enhancing cytarabine treatment to further improve treatment outcome and reduce relapse of ML-DS patients.
The paradox of myeloid leukemia of Down syndrome
Grant Number
R21CA270718
NIH Institute
NCI
Mechanism
R21
Down syndrome (DS) children have a significantly higher risk of developing acute leukemias compared to non- DS children. The goal of this proposal is to determine the role of cystathionine-ß-synthase (CBS) in oxidative phosphorylation and cytarabine sensitivity/resistance in myeloid leukemia associated with DS (ML-DS). This proposal will also identify a novel treatment strategy for cytarabine-resistant (refractory/relapsed) ML-DS.