Maternal acetaminophen use and childhood cancer

In the US, the population prevalence of Down syndrome is 250,000 persons, and 6000 children with Down syndrome are born in the US each year; these numbers are expected to rise with greater abortion restrictions. With increasing prevalence and longer lifespans of individuals with DS, it is vital to understand common comorbidities across the lifespan for more appropriate screening practices, improved utilization of health care resources, tailored medical care guidelines, and improved management of care. Herein we propose to utilize large national databases to examine the prevalence and risk of comorbid conditions in Down syndrome, with adjustment for potential confounding variables such as maternal age.