Establishing foundational tools and datasets for investigation of NSD1 gene function in neural development

This project proposes to develop novel human induced pluripotent stem cell (iPSC) tools to study NSD1 haploinsufficiency and to generate pilot data on NSD1 molecular function in human neurons. These tools and datasets will be used to accelerate our understanding of how NSD1 haploinsufficiency drives the neurodevelopmental phenotypes observed in Sotos syndrome.