Modifiers of Down Syndrome Co-occurring Phenotypes

NARRATIVE The proposed research is relevant to public health because it will create new mouse models that are more like the human Down syndrome condition to identify modifier genes and molecules contributing to the incidence and severity of DS skeletal and cognitive phenotypes, as well as differences between sexes in these phenotypes. This research will provide a foundation to change how the gene-phenotype relationships are deduced in Down syndrome and other syndromic disorders, propose relevant treatments, and ensure that that all children have the chance to achieve their full potential free from disease or disability.