Molecular mechanism of dysregulated airway antiviral responses in children with Trisomy 21

Statement: We will elucidate the mechanism mediating the dysregulation of airway antiviral and antioxidative responses in Down Syndrome (DS). This may provide the foundation to develop novel approaches to prevent severe respiratory infections caused by RSV and other viruses (e.g. SARS-CoV-2) in children and adults with DS.