Investigating epigenetic mechanisms in Down syndrome using human cellular models

This project uses human induced pluripotent stem cell (iPSC) models to investigate the novel hypothesis that dysregulation of histone modifications in Down syndrome (DS) drives downstream molecular and cellular phenotypes. In addition to elucidating fundamental mechanisms of epigenetic re-wiring in DS, this project will explore a set of key unanswered questions in the field, and test the utility of epigenetic modifiers for normalizing histone phenotypes which has the exiting potential to illuminate new therapeutic targets.