Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt

This IDDRC administrative supplement application for Vanderbilt University's Intellectual and Developmental Disabilities Research Center (IDDRC), based in Vanderbilt's Kennedy Center (VKC), will use leverage existing electronic medical record information and biological samples to develop a deeper understanding of critical issues in Down Syndrome (DS) and provide and infrastructure for future analyses. Specifically, this work will: 1) identify unrecognized clinical features in DS and determine whether there are clinical features that differ between sexes and demographic groups; 2) develop predictive models based on EMR data for risk of clinical features or interventions in DS; 3) Identify genetic risk factors for congenital heart disease in DS. Finally, we will expand the prospective data collection in order to allow for future substantial and substantive DS research.