Research Training in Rheumatology – Down Syndrome Supplement

Trisomy 21 is the most common human chromosomal disorder, occurring in ~1/700 live births, and results in the condition known as Down Syndrome (DS). Individuals with DS are at increased risk for a variety of autoimmune diseases including disorders casing bleeding in the lungs. The research proposed in this application will improve the identification and management of autoimmune lung disease among DS patients, thereby addressing an unmet health need, informing the medical community as to the basis for these disorders, and improving the health care of all individuals.