Molecular mechanisms of oral deficiencies in Down syndrome

Lacruz, Rodrigo S

Summary

We will investigate if individuals with Down syndrome (DS) are predisposed to develop Sjogren’s-like disease (SjD) using the DS mouse model Dp16 mice, which will be treated with agonists of toll-like receptors (TLR) and interferon stimulation (e.g. DMXAA) to address if they develop enhanced SjD.

Grant Number

3R01DE032846-01S1

NIH Institute

NIDCR

Mechanism

R01

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