Genomic and functional approaches to characterize Chr1q gains in cancer

Approximately 25% of human tumors harbor a gain of the “q” arm of chromosome 1, but the functional consequences of this large-scale dosage change are unknown. We will develop and employ novel computational and genetic strategies to characterize the functional consequences of this alteration. These studies will shed light on the physiological effects of a ubiquitous but poorly-understood feature of tumor genomes.