DYRK1A interaction network in development and disease

Abnormal dosage of the Down syndrome candidate DYRK1A gene results in developmental syndromes characterized by intellectual disability and craniofacial abnormalities. However, the function and regulation of DYRK1A are not fully understood. In this study, we will use multidisciplinary approach to characterize the role of novel interaction partners in the DYRK1A function and Xenopus embryo development.