Sannar, Elise M PhD

Among the many co-occurring conditions that can affect individuals with Down syndrome, the neurological condition known as Down Syndrome Regression Disorder (DSRD) is undoubtedly one of the most detrimental, including symptoms such as catatonia, mutism, depersonalization, loss of ability to perform activities of daily living, hallucinations, delusions, and aggression. This project consists of a research-intensive clinical trial to compare the relative safety and efficacy of three alternative therapeutic approaches in DSRD, including two promising immune-modulatory medicines. Results from this project will produce much needed information about the etiology of DSRD and its response to diverse interventions.