Researchers
Glass, Tiffany PHD
University of Wisconsin, Madison
INCLUDE Grants
Tongue maturation deficits in a mouse model of Down syndrome
Grant Number
R01HD104640
NIH Institute
NICHD
Mechanism
R01
Down syndrome (DS) is associated with atypical tongue movement that contributes to devastating challenges with communication and feeding, but the biological mechanisms underlying these challenges are not known. This research will investigate early postnatal changes in tongue muscles and brainstem in a mouse model of DS at three different timepoints during oromotor development, as well as after two different oromotor activity conditions.
Mechanisms of Down syndrome-associated swallowing dysfunction in mouse models
Grant Number
R01DC019735
NIH Institute
NIDCD
Mechanism
R01
Down syndrome (DS) is associated with difficulties in speech, breathing, and swallowing, but the reasons for these difficulties remain unknown. Mouse models can be used to study the potential mechanisms for impairment of these critical activities. The proposed research will study how aging impacts swallowing function in adult mouse models of DS and will generate new mouse models to reveal the molecular underpinnings of swallowing dysfunction associated with DS, thereby expanding knowledge of this important clinical manifestation.