Researchers
Suva, Larry J PhD
Texas A&M AgriLife Research
INCLUDE Grants
Understanding the skeleton in Down Syndrome
Grant Number
R01HD102909
NIH Institute
NICHD
Mechanism
R01
The long-term goal of this research is to understand bone anabolism, cessation of treatment and fracture repair in the setting of Down Syndrome (DS). These studies will provide important new insights regarding the specific involvement of genes associated with trisomy 21 and the regulation of skeletal homeostasis. The application provides the first ever assessment of fracture repair and the impact of anabolic treatment cessation in DS.
Publications
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Bone
Altered digit tip blastema differentiation and bone regeneration in skeletally mature Ts65Dn Down syndrome mice. -
Bone
Male Down syndrome Ts65Dn mice have impaired bone regeneration. -
Advanced materials (Deerfield Beach, Fla.)
Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome. -
Bone
Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome).